Human γδ T cells
Identifieur interne : 004C48 ( Main/Exploration ); précédent : 004C47; suivant : 004C49Human γδ T cells
Auteurs : Susann Beetz [Allemagne] ; Lothar Marischen [Allemagne] ; Dieter Kabelitz [Allemagne] ; Daniela Wesch [Allemagne]Source :
- Immunologic Research [ 0257-277X ] ; 2007-03-01.
English descriptors
Abstract
Abstract: A numerically small subset of human T lymphocytes expresses a γδ T cell receptor (TCR). These γδ T cells share certain effector functions with αβ T cells as well as with NK cells and NKT cells. The major peripheral blood γδ T cell subset in healthy adults expresses a Vγ9Vδ2 TCR, which recognizes small phosphorylated metabolites referred to as phosphoantigens. Vδ1 γδ T cells mainly occur in the intestine. They recognize the stress-induced MICA/B and CD1c. Furthermore, γδ T cells express a variety of NK cell and pattern-recognition receptors which are responsible for the “fine-tuning” of effector functions. In recent years, γδ T cells start to emerge as a rewarding target for immunotherapeutic strategies against viral infections and cancer. A better understanding of factors that modulate γδ T cell function will further eluminate the potential of these cells.
Url:
DOI: 10.1007/BF02685893
Affiliations:
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Le document en format XML
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These γδ T cells share certain effector functions with αβ T cells as well as with NK cells and NKT cells. The major peripheral blood γδ T cell subset in healthy adults expresses a Vγ9Vδ2 TCR, which recognizes small phosphorylated metabolites referred to as phosphoantigens. Vδ1 γδ T cells mainly occur in the intestine. They recognize the stress-induced MICA/B and CD1c. Furthermore, γδ T cells express a variety of NK cell and pattern-recognition receptors which are responsible for the “fine-tuning” of effector functions. In recent years, γδ T cells start to emerge as a rewarding target for immunotherapeutic strategies against viral infections and cancer. 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